Early results were reported from an independent study in Japan using
adipose-derived stem and regenerative cells for breast augmentation.
Early results on the first three patients from this
investigator-initiated study showed the increase in breast volume was
maintained at three months and that the tissue remained soft and
natural. The findings were reported earlier this week by the
investigator, Tatsuro Kamakura, M.D., Chief Medical Officer of Cosmetic
Surgery Seishin, at the 94th Bi-Annual Congress
of the Japan Society of Aesthetic Surgery (www.biyou-clinic.jp/jsas/).
"Volume retention and softness of tissue at three-months is extremely
encouraging compared to typical outcomes in non-cell-enhanced fat
transfers,” said Dr. Kamakura. “If
volume retention holds at nine-months, the augmentations can be expected
to be permanent. Such results offer women a revolutionary new cosmetic
surgery option for smaller volume augmentations, where a more natural
look and feel is desired."
At three months, breast circumference in the first three patients
remained stable at an average increase of 4 centimeters, which is
equivalent to a 1.6 cup size increase. An average net volume of 160mL
(less saline) of cell enhanced fat tissue was transplanted into each
breast of each patient. The procedure to date has been found safe with
no report of any adverse events. Patient follow-up is ongoing in this 20
patient investigator-initiated study. Nine-month results will be
reported in early 2009, shortly after the last patient follow-up.
The study is using a procedure whereby a woman’s
fat tissue is enriched with her own adipose derived stem and
regenerative cells to create a natural filler. This technique is
referred to as cell-enhanced augmentation. The cells in the study were
made available at the time of surgery using the Celution®
800 System from Cytori Therapeutics (NASDAQ: CYTX). Further results from
the study will be available following a nine month assessment of the
primary endpoints of cosmetic improvement and volume retention.
Fat, known medically as adipose tissue, is the body's richest known
source of regenerative cells. Adipose-derived regenerative cells include
adult stem cells in addition to other important cell types that have
been shown pre-clinically to improve tissue retention compared to non-
'cell enhanced' tissue transfers.
