LONDON -- (Marketwire) -- 10/06/08 --

NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Name of company

Smith & Nephew plc

2. Name of shareholder having a major interest

Prudential plc

3. Please state whether notification indicates that it is in
respect of holding of the shareholder named in 2 above or in
respect of a non-beneficial interest or in the case of an
individual holder if it is a holding of that person's spouse
or children under the age of 18

Non-beneficial

4. Name of the registered holder(s) and, if more than one holder,
the number of shares held by each of them

Prudential Plc

5. Number of shares / amount of stock acquired

None

6. Percentage of issued class

7. Number of shares / amount of stock disposed

8. Percentage of issued class

9. Class of security

Ordinary shares of US 20 cents

10. Date of transaction

01.10.2008

11. Date company informed

03.10.2008

12. Total holding following this notification

26,628,151

13. Total percentage holding of issued class following this
notification

Less 3%

14. Any additional information

Prudential plcno longer have a notifiable interest in Smith &
Nephew

15. Name of contact and telephone number for queries

Gemma Parsons - Assistant Company Secretary
020 7960 2228

16. Name and signature of authorised company official responsible
for making this notification

Gemma Parsons - Assistant Company Secretary

Date of notification

06.10.2008

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                    This information is provided by RNS
          The company news service from the London Stock Exchange
END