FORM 3UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
Silva Paul M
(Last)(First)(Middle)
C/O VERTEX PHARMACEUTICALS INCORPORATED, 130 WAVERLY STREET
(Street)
CAMBRIDGEMA02139
(City)(State)(Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
09/29/2008		3. Issuer Name and Ticker or Trading Symbol
VERTEX PHARMACEUTICALS INC / MA [VRTX]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
V.P. and Corporate Controller
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 2,250 (1)
D
 
Common Stock 1,000 (2)
D
 
Common Stock 500 (3)
D
 
Common Stock 300
I
401(k)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)4. Conversion or Excercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option 11/13/2007(4)08/12/2017 Common Stock 7,500 $ 36.27 D  
Stock Option 05/07/2008(5)02/06/2018 Common Stock 7,500 $ 18.93 D  
Stock Option 10/24/2008(6)07/23/2018 Common Stock 3,750 $ 32.16 D  
Explanation of Responses:
1. Stock grant made under 2006 Stock and Option Plan, 750 shares vesting on 8/13/2009; 750 shares vesting 8/13/2010; and 750 shares vesting on 8/13/2011.
2. Stock grant made under 2006 Stock and Option Plan vesting in four equal annual installments from 2/7/2008.
3. Stock grant made under 2006 Stock and Option Plan vesting in four equal annual installments from 7/24/2008.
4. Right to buy shares of Common Stock under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 8/13/07.
5. Right to buy shares of Common Stock under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 2/7/08.
6. Right to buy shares of Common Stock under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from 7/24/08.
Valerie L. Andrews, Attorney-In-Fact09/30/2008
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.



 
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